March 6, 2015
It’s been an eventful week. On Monday, people started forwarding me the link for the new issue of The Scientist. The reason is that the issue delves into some of the most important breakthroughs in anti-aging science, which I’ve been talking about for the last several years.
January 8, 2016
Opinion polls show that the American mood right now is historically dismal. By lots of measures, things actually look pretty bleak. Real employment statistics are awful. Investment in new business is catastrophically low, which further hurts job growth prospects.
March 28, 2016
I hope you’ll forgive me for being brief this week. Despite the help of an incredibly talented team, I’m a little overwhelmed by the many last minute tasks associated with finishing my book, The Methuselah Effect.
May 9, 2016
As promised last week, I’ve got a video for you of an interview I did with Elizabeth Parrish, who underwent the first gene therapy for the reversal of aging in a human. Also taking part in the interview is Dr. William Andrews, her scientific advisor.
May 16, 2016
Extending life spans is not just a medical goal. It is an economic and political necessity.
July 5, 2016
Michael West, known as the father of regenerative medicine, gave a talk last week that historians will remember as the world’s first look at the biotechnology that changed everything forever. At the annual meeting of Mensa, he reported on the progress of regenerative medicine—from the stem cell breakthroughs that he pioneered to his current research.
August 15, 2016
Silicon Valley is taking on healthcare. Armed with billions and a drive to innovate, tech giants have the potential to solve the biggest medical challenges and shake up the regulators.
September 6, 2016
If you needed proof that the educated, wealthy, and powerful are just as susceptible to myths parading as science as anyone else—the over-population hysteria is a perfect example. It’s not the only discredited social cause, but the focus on total population numbers distracts us from very real demographic problems. This puts the world on a path to economic disaster.
January 23, 2017
In the last eight years, the US debt has basically doubled to almost $20 trillion. But many still portray the economy as fundamentally healthy. It’s like a family that claims high levels of spending are proof that everything’s great… even while maxing out the credit cards. At some point, it has to end. And high levels of debt will make recovery even more difficult.
March 6, 2017
In 2011, scientists made one of the most important discoveries in the history of AI development. They found that graphics processing units (GPUs) are far better at simulating biological learning than central processing units (CPUs).
March 27, 2017
We are in the midst of an unprecedented transformation. In the first part of the 21st century, advances in computer technology have dramatically increased the pace of biological sciences. In the previous century, life spans had already nearly doubled since the beginning of the 20th century. This trend will accelerate.
July 10, 2017
Last year, we began to see articles in the press conceding that overpopulation wasn’t going to end civilization. This year, we’re seeing reports on the real population problems—depopulation and aging.
July 17, 2017
Quite a few people have asked for an update on the Targeting Aging with Metformin (TAME) trial. If you’ve been reading my digest, you know that TAME is the effort to get metformin (the common diabetes drug) approved by the FDA as an anti-aging drug.
December 18, 2017
Several newly published studies add to the evidence that vitamin nicotinamide riboside is geroprotective. They also shed light on some fascinating discoveries about the role of mitochondria.
January 15, 2018
The ongoing revelation regarding the importance of mitochondria may be the biggest scientific story of our era. These intelligent, bacteria-like colonies of energy producers inside our cells, passed down by our mothers since the dawn of humanity, may be the key to nearly unbelievable medical and anti-aging breakthroughs.
April 9, 2018
For the last few weeks, I’ve been having a conversation with a friend and reader about the difference between geroprotection and induced tissue regeneration (iTR). Based on those conversations, it’s clear that I haven’t done a good job of differentiating these two concepts.
April 16, 2018
Last week, I wrote the first part of this series to differentiate induced tissue regeneration (iTR) and geroprotectors. In a nutshell, it is the difference between rejuvenation and regeneration.
June 11, 2018
Rapa Nui, also known as Easter Island, is a smallish island over 2,100 miles away from the coast of Chile, the closest continental point. It is known mostly for the hundreds of Moai—giant stone statues placed around the island by Polynesian builders—though history will remember it as the source of rapamycin.
June 18, 2018
As off-label use of rapamycin spreads, I’m hearing anecdotal reports supporting the theory that the anti-aging effects demonstrated in multiple animal trials also apply to humans. If the benefits are comparable, low-dose rapamycin may add more than a decade to users’ healthspans.